Empirico, a clinical-stage biotechnology company that combines unmatched expertise in human genetics-driven target discovery with world-class capabilities in siRNA medicines is seeking a chemist with an interest in solid-phase oligonucleotide synthesis and analytics. This is an excellent opportunity for a highly motivated, creative scientist to be a vital member of our team.

Responsibilities:

You will be responsible for supporting the synthesis, purification, and characterization of oligonucleotides and their conjugates, and optimizing methodologies to support the development of siRNA medicines. The ideal candidate will have experience in organic and analytical chemistry and both upstream and downstream oligonucleotide manufacturing processes. A key focus of this role will be developing scalable processes suitable for technology transfer to CDMOs. You will be expected to –
Perform solid-phase synthesis, purification, and characterization of oligonucleotides
Develop and optimize scalable upstream (synthesis) and downstream (purification, formulation) manufacturing processes
Support process development activities to enable successful technology transfer to CDMOs
Analyze, interpret, and clearly communicate synthetic and analytical data
Present findings to senior staff and cross-functional teams
Troubleshoot and refine synthesis and purification protocols
Manage multiple projects simultaneously

Requirements:

This position requires a BS in Chemistry with at least 7 years of relevant industry experience, or an MS in Organic Chemistry, Biochemistry, or Chemical Engineering with a minimum of 3 years of experience, or a PhD with at least 1 year of relevant experience
Minimum 1 year of experience working in a cGMP environment
Hands-on proficiency with analytical instrumentation such as NMR, LC-MS, and RP-HPLC
1–7 years of relevant work experience, preferably in solid-phase oligonucleotide synthesis, and familiarity with both upstream and downstream oligonucleotide manufacturing processes
Demonstrated ability in analytical and purification method development using RPIP-HPLC, AEX-HPLC, UV, MALDI, and HRMS
Background in process development and technology transfer to CDMOs, including development of scalable purification and formulation methodologies
Working knowledge of tangential flow filtration (TFF) method development
Applicants must have authorization to work in the U.S

The estimated annual base salary range for this role is $90,000 to $120,000. Individual compensation decisions will be based on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. We offer a wide range of benefits including a retirement savings plan (with company match), paid vacation, holidays, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

About Empirico: Empirico is a clinical-stage biotechnology company that discovers and develops siRNA medicines designed to mimic naturally-occurring genetic variants that confer beneficial effects on health and disease. Empirico’s two foundational and proprietary technology platforms - the Precision Insights Platform™ for genetically-validated target discovery, and the siRCH™ platform for the discovery and development of siRNA medicines - enable Empirico and its collaborators to rapidly advance programs from the discovery and validation of novel targets to clinically-viable therapeutics. Empirico’s exceptional internal capabilities, augmented by those of its partners, are driving the advancement of a growing and differentiated pipeline of wholly-owned and partnered programs for a broad range of common diseases with unmet medical need. Empirico is headquartered in San Diego, CA with a major second R&D site in Madison, WI.

We’re striving to build a strong culture of inclusivity, transparency and collaboration at Empirico, where our diverse and equitable workforce is empowered to contribute to our mission. We always seek the best candidate for the position and encourage you to apply even if your experience or qualifications don’t match up exactly with the job description. Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

To All Agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

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